TRANSIENT AMNESIA FREE

From a defined population, the minimum annual incidence of TGA has been estimated to be 3.00 in 1 study. 1 Orientation in space and time is impaired while consciousness remains undisturbed. Transient global amnesia (TGA) is characterized by anterograde memory disturbance of sudden onset that lasts for 1 to 24 hours. Other pathophysiologic mechanisms need to be explored. A comprehensive diagnostic workup also provided no evidence for a higher rate of cerebrovascular disorder-related abnormalities in either the total group of TGA patients or TGA DWI+ patients.Ĭonclusions- These findings do not support a cerebrovascular etiology of TGA, even in those individuals showing acute DWI lesions. The vascular risk profile of TGA patients and concomitant changes on brain MRI were comparable with those of healthy controls and did not show significant differences between DWI+ and DWI− subjects. They were all small and located in the mesiotemporal region (9 left hemisphere, 5 right hemisphere). Results- DWI lesions were observed in 10 patients with TGA (11.5% mean±SD age, 68.3±5.4 years 8 women).

TRANSIENT AMNESIA FREE

A 1:2 age- and sex-matched sample of 172 elderly subjects (mean±SD age, 65.6☙.3 years 62% female) free of neuropsychiatric disease served for comparison. Vascular risk factors and findings from duplex sonography, ECG, and echocardiography were recorded.

Brain MRI at 1.5 T was assessed for DWI lesions exhibiting restricted diffusion (ie, DWI+), white-matter hyperintensities, lacunes, and chronic infarcts (median time lag to clinical onset, 66.6±54.6 hours). Methods- We retrospectively identified 86 patients hospitalized for TGA (mean±SD age, 65.9☑0.9 years 62% female). We tested this hypothesis by comparing vascular risk factors, magnetic resonance imaging (MRI) markers of cerebral small-vessel disease, and other evidence of a cerebrovascular disorder between TGA patients with (DWI+) and without (DWI−) DWI lesions and normal community-based controls.

Customer Service and Ordering Informationīackground and Purpose- A hypoxic-ischemic origin of transient global amnesia (TGA) has been suggested on the basis of the observation of infarctlike diffusion-weighted imaging (DWI) abnormalities in some affected individuals.

Stroke: Vascular and Interventional Neurology.

Journal of the American Heart Association (JAHA).

Circ: Cardiovascular Quality & Outcomes.

Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).

Transient amnesia